Mfg Part Number
Ab02035-1.1
Vector Labs Ab02035-1.1 Anti-FGF1 [1C9], Mouse IgG1, kappa (200 μg)
Quick Overview
The original antibody was generated by immunizing mice with human FGF-1.
$517.40
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | 1C9 |
| Synonyms: | FGF-1; aFGF; ECGF; HBGF-1; Fibroblast growth factor 1; Acidic fibroblast growth factor; Endothelial cell growth factor; Heparin-binding growth factor 1 |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; IP; WB; IHC; IF |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | scFv |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This full-length, reformatted mouse antibody was made using the variable domain sequences of the original Mouse scFv format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody binds the human FGF-1. |
| Application Notes: | FGF-1 plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Studies have shown that FGF-1 is overexpressed in the early stages of several kinds of cancer. Functional analysis showed that the overexpressed scFv1C9 in MCF-7 cells targeted endogenous FGF-1 and prevented the translocation of FGF-1 into the nucleus, resulting in the blockade of the intracrine pathway of FGF-1, which caused the G1 arrest by p21 up-regulation. Binding of scFv1C9 to FGF-1 was confirmed with ELISA. The antigen-binding ability of scFv1C9 with endogenous FGF-1 was confirmed in vivo by using of an immunoprecipitation assay. FGF-1 immunohistochemical staining of breast ductal carcinoma tissues was used to to demonstrate that FGF-1 was increasingly expressed in breast cancer tissues.(PMID:21360642). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |