Mfg Part Number
Ab02040-2.0
Vector Labs Ab02040-2.0 Anti-17-Hydroxyprogesterone [4B2 (4B2.2.1)], Mouse IgG2a, kappa (100 μg)
Quick Overview
The original antibody was generated by immunizing BALB/c mice with 17-OHP-bovine serum albumin conjugate as an immunogen.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | 4B2 (4B2.2.1) |
| Synonyms: | 17-OH; 17-OHP; 17α-hydroxyprogesterone |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; RIA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody binds 17α-hydroxyprogesterone (17-OHP). |
| Application Notes: | This antibody has good affinity for 17-OHP, a chemical intermediate involved in the biosynthesis of many endogenous steroids like androgens, estrogens, glucocorticoids, and mineralocorticoids, as well as neurosteroids. Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder caused by the deficiency of one of the five enzymes involved in the biosynthesis of corticosteroids. The most common form of the disease is the deficiency of 21-hydroxylase that catalyses the production of cortisol. Due to lack of this enzyme there is an accumulation of high levels of 17α-hydroxyprogesterone (17-OHP). This antibody is therefore recommended for detection of high levels of 17-OHP caused by CAH. Fluorescence enzyme immunoassay and micro-enzyme immunoassay for 17-OHP showed that 4B2.2.3 has lowest cross reactivity with other steroids (PMID: 3312820). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |