Mfg Part Number
Ab02064-10.0
Vector Labs Ab02064-10.0 Anti-CEA [BW431/26], Human IgG1, kappa (200 μg)
Quick Overview
The original antibody was generated by immunizing mice with CEA positive adenocarcinoma cells preferably from lungs.
$517.40
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | BW431/26 |
| Synonyms: | Carcinoembryonic antigen; Carcinoembryonic antigen-related cell adhesion molecule 5; CEACAM5; Meconium antigen 100; CD66e |
| Amount: | 200 μg |
| Application Codes Clone: | Immunoscintigraphy |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG3 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG3 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody recognizes and binds human carcinoembryonic antigen in its purified state as well as on tissue sections. |
| Application Notes: | Technetium 99-labeled (Tc-99m) BW431/26 has been used in the diagnosis and detection of colorectal carcinomas, breast cancers, bladder carcinomas, lung adenocarcinomas and their recurrences by immunoscintigraphy (PMID: 2602902, 2662074, 2685692, 2297747, 2157833, 2166552, 2383485, 1984945 ). The use of Tc-99m-BW 431/26 immunoconjugates in immunoscintigraphy resulted in reduction of radiation dose for the patient down to 5% of the dose applied as compared with I-131 labelled MAbs (PMID: 3262953). Humanized version of this antibody also shows similar binding affinity as compared to its murine parent antibody (PMID: 1762576). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |