Mfg Part Number
Ab02068-10.3
Vector Labs Ab02068-10.3 Anti-Glycoprotein D of HSV [Fd138-80], Human IgG1, Fc Silent™, kappa (200 μg)
Quick Overview
This antibody was raised against Herpes simplex virus.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | Fd138-80 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | gD; HSV gD; Herpes simplex virus; Envelope glycoprotein D; US6 |
| Amount: | 200 μg |
| Application Codes Clone: | FC; IF; NTRL |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody recognizes and binds a shared epitope of glycoprotein D (gD) of HSV1 and HSV2. |
| Application Notes: | This antibody protected mice against encephalitis and death following ocular inoculation with the virus. Murine Fd138-80 has been shown to neutralize HSV-1 in vitro without complement. Humanized and murine Fd138-80 were able to cause a 90% plaque reduction at an antibody concentration of 7 nM (1 ug/ml) (PMID: 3010559, 3030642, 2838428). The binding of antibody to HSV-infected Vero cells was tested using fluorocytometry. Immunostaining was used to view Vero cell monolayers infected with HSV-1 and total cell lysis in the presence of Fd138-80. Humanized version of this antibody has similar affinity as compared to its murine version (PMID: 1849279). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |