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Mfg Part Number

Ab02090-3.3

Vector Labs Ab02090-3.3 Anti-TGEV Coronavirus Spike glycoprotein [1AF10], Mouse IgG2b, Fc Silent™, kappa (200 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated by immunizing mice with native transmissible gastroenteritis virus (TGEV).

$517.40

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Description

Product Class: Purified
Clone ID: 1AF10
Heavy Chain Modification: Fc Silent™
Synonyms: Spike glycoprotein; spike protein; S glycoprotein; E2; Peplomer protein; Porcine transmissible gastroenteritis coronavirus; 1A.F10
Amount: 200 μg
Application Codes Clone: NTRL; WB; RIA; ELISA; Crystallization
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody recognizes the amino acid sequence 537-MKRSGYGQPIA-547 within site A of the S protein, located in the receptor-binding motif (RBM) region of the transmissible gastroenteritis coronavirus (TGEV).
Application Notes: This antibody is capable of neutralizing TGEV and recognizing it in an immunodot blot assay. The antigenic site of the S glycoprotein of TGEV where the monoclonal antibody binds was identified using competitive RIA (Correa et al., 1988; PMID: 2453977). Additionally, this antibody can recognize the TGEV spike protein in ELISA and be used to detect site A of the S protein in Western blot analysis, specifically for investigating the effect of glycosylation on antibody binding (Gebauer et al., 1991; PMID: 1711257). The Fab format of this antibody was crystallized in complex with the TGEV coronavirus Spike fragment (Reguera et al., 2012; PMID: 22876187).

Product Class:	Purified
Clone ID:	1AF10
Heavy Chain Modification:	Fc Silent™
Synonyms:	Spike glycoprotein; spike protein; S glycoprotein; E2; Peplomer protein; Porcine transmissible gastroenteritis coronavirus; 1A.F10
Amount:	200 μg
Application Codes Clone:	NTRL; WB; RIA; ELISA; Crystallization
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody recognizes the amino acid sequence 537-MKRSGYGQPIA-547 within site A of the S protein, located in the receptor-binding motif (RBM) region of the transmissible gastroenteritis coronavirus (TGEV).
Application Notes:	This antibody is capable of neutralizing TGEV and recognizing it in an immunodot blot assay. The antigenic site of the S glycoprotein of TGEV where the monoclonal antibody binds was identified using competitive RIA (Correa et al., 1988; PMID: 2453977). Additionally, this antibody can recognize the TGEV spike protein in ELISA and be used to detect site A of the S protein in Western blot analysis, specifically for investigating the effect of glycosylation on antibody binding (Gebauer et al., 1991; PMID: 1711257). The Fab format of this antibody was crystallized in complex with the TGEV coronavirus Spike fragment (Reguera et al., 2012; PMID: 22876187).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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