Mfg Part Number
Ab02093-201.1
Vector Labs Ab02093-201.1 Anti-CPV capsid [A3B10 (MAb 8)], Dog IgG2 (IgG-B), kappa (200 μg)
Quick Overview
The original antibody was generated by immunizing mice with canine parvovirus virus.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | A3B10 (MAb 8) |
| Synonyms: | Canine Parvovirus Capsid; Site B; Capsid protein VP2; Coat protein VP2; Feline Panleukopenia Virus |
| Amount: | 200 μg |
| Application Codes Clone: | NTRL; IP; ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric dog antibody was made using the variable domain sequences of the original Mouse IgG2a format for improved compatibility with existing reagents assays and techniques. |
| Specificity Statement: | This antibody recognizes and binds the site B of the intact canine parvovirus capsid. It also cross reacts with feline panleukopenia virus. This antibody recognizes a conformational epitope on the viral capsid and does not bind denatured or heat treated virus. |
| Application Notes: | This antibody is capable of neutralizing canine parvovirus and inhibit the hemagglutination of the homologous virus. This antibody can immunoprecipitate capsid protein (PMID: 6194613). Mab A3B10 is non-reactive on Western blots from gels of denatured CPV (PMID: 8259653). The mode of Fab binding suggests that the A3B10 neutralizing antibody cannot bind bivalently to the capsid across the two-fold axes (PMID: 7522904). The binding of A3B10 to intact capsid was tested using ELISA (PMID: 9770425). The scFv version of the antibody bound viral capsid with a 10-20 fold lower avidity as compared to the intact IgG (PMID: 10753725). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |