Mfg Part Number
Ab02116-23.0
Vector Labs Ab02116-23.0 Anti-Nav1.1 Na+ channel [K74/71], Rabbit IgG, kappa (200 μg)
Quick Overview
This antibody was raised by immunising BALB/c mice with a fusion protein consisting of the cytoplasmic C-terminus (amino acids 1929-2009) of rat Nav1.1.
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| Product Class: | Purified |
|---|---|
| Clone ID: | K74/71 |
| Synonyms: | K74/71R; Voltage-gated sodium channel subunit alpha Nav1.1; Sodium channel protein type 1 subunit alpha; Sodium channel protein brain I subunit alpha; Scn1a; NAC1; SCN1 |
| Amount: | 200 μg |
| Application Codes Clone: | IB; IHC; IP; ELISA; IF |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for Nav1.1. It does not cross-react with Nav1.2, Nav1.3 of Nav1.6. |
| Application Notes: | The specificity of this antibody has been confirmed in ELISA against the GST-Nav1.1 fusion protein and immunofluorescence analysis of COS cells expressing full-length human Nav1.1 (Van Wart et al, 2005). This antibody has been used in immunoblot analysis of adult rat brain membranes, where it labels a single band at the same position as that labelled with pan-specific anti-Nav antibody K58/35 (Van Wart et al, 2005). Additionally, this antibody has been used in immunohistochemical analysis of adult rat hippocampus and whole brain sections (Van Wart et al, 2005; Andrews et al, 2019; PMID:30667360). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |