Mfg Part Number
Ab02198-10.0
Vector Labs Ab02198-10.0 Anti-HA [CR8020], Human IgG1, kappa (200 μg)
Quick Overview
The original antibody was generated from the PBMCs of donors vaccinated 7 days earlier with the trivalent inactivated influenza vaccine for the 2006-2007 season (containing A/New Caledonia/20/1999 (H1N1), A/Wisconsin/67/2005 (H3N2), and B/Malaysia/2506/2004).
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | CR8020 |
| Synonyms: | Hemagglutinin; Avian Influenza Virus; AIV; H3N2; H7N7; Influenza A virus |
| Amount: | 200 μg |
| Application Codes Clone: | NTRL; Therapeutic; FC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody binds hemaglutinin of most group 2 influenza viruses including H3N2 and H7N7. |
| Application Notes: | CR8020 has a broad neutralizing activity against most group 2 viruses, including H3N2 and H7N7. The crystal structure of Fab CR8020 with the 1968 pandemic H3 hemagglutinin (HA) reveals a highly conserved epitope in the HA stalk distinct from the epitope recognized by the VH1-69 group 1 antibodies. CR8020 binds most group 2 HAs with high affinity, including H3 isolates. Flow cytometry was used to test the ability of the antibody to bind different structural HA conformations of recombinant influenza A subtype H3. Therapeutic treatment with 15 mg/kg of CR8020 up to 2 days after infection with H3N2 completely prevented mortality, whereas 50% of the mice treated 3 days after infection were protected (PMID: 21737702). It is reported that Oseltamivir/Zanamivir may congruously improve the therapeutic efficacy of CR8020 (PMID: 22693576). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |