Mfg Part Number
Ab02199-10.3
Vector Labs Ab02199-10.3 Anti-HA [CR6261], Human IgG1, Fc Silent™, kappa (200 μg)
Quick Overview
The original antibody was isolated using phage display from the IgM+ memory B cells of a healthy individual vaccinated against influenza.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | CR6261 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | Hemagglutinin; Avian Influenza Virus; AIV; H1N1; H5N1; Influenza A virus |
| Amount: | 200 μg |
| Application Codes Clone: | NTRL; Therapeutic |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody binds hemaglutinin of most group 1 influenza viruses. CR6261 recognizes a highly conserved helical region in the membrane-proximal stem of HA1/HA2. |
| Application Notes: | The antibody neutralizes the virus by blocking conformational rearrangements associated with membrane fusion. CR6261 neutralizes multiple influenza subtypes, including H1, H2, H5, H6, H8, and H9, and protects mice from lethal challenge with H1N1 and H5N1 viruses when administered up to five days post-infection (PMID: 19251591). It is reported that Oseltamivir/Zanamivir may congruously improve the therapeutic efficacy of CR6261 (PMID: 22693576). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |