Mfg Part Number
Ab02225-23.0
Vector Labs Ab02225-23.0 Anti-HIV-1 gp120 [694-D], Rabbit IgG, lambda (200 μg)
Quick Overview
The original version of this antibody was raised by Epstein-Bar virus (EBV) transformation of peripheral blood mononuclear cells obtained from HIV-infected subjects followed by fusion with the SHM-D33 heteromyeloma (Buchbinder et al., 1992; pmid: 1466965).
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | 694-D |
| Synonyms: | Envelope glycoprotein; Envelope glycoprotein gp160; Env polyprotein; Surface protein gp120; SU; Glycoprotein 120; 694/98-D; 694/98; 694.8; 694/98D; 694-98D |
| Amount: | 200 μg |
| Application Codes Clone: | Neutralizing; WB; ELISA; IF; functional assays |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | 694-D recognizes a neutralizing epitope of the hypervariable V3 loop of HIV-1 gp120. |
| Application Notes: | This antibody was demonstrated to be neutralizing against HIV (Buchbinder et al., 1992; pmid: 1466965). It can be used synergistically with other neutralizing HIV antibodies (such as 447-D). This clone inhibits the binding of gp120 to soluble recombinant CD4 (Buchbinder et al., 1992; pmid: 1466965). Consequently, this antibody is recommended for research on the develpment of successful treatment and prevention of HIV infection, as effective neutralizing antibodies are capable of depleting the viral load in patients exposed to the virus. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |