Vector Labs Ab02238-10.3 Anti-CD66b [BW 250/183], Human IgG1, Fc Silent™, kappa (200 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: BW 250/183
Heavy Chain Modification: Fc Silent™
Synonyms: CEACAM8; CGM6; Carcinoembryonic antigen-related cell adhesion molecule 8; Carcinoembryonic antigen CGM6; CD67 antigen; Non-specific cross-reacting antigen; NCA-95
Amount: 200 μg
Application Codes Clone: Immunoscintigraphy; Immunocytochemical staining; Therapeutic; IF; FC
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody binds the human CD66b, which is expressed on the surface of granulocytes.
Application Notes: This murine antibody reacted with granulocytes, colon mucosa and faintly with pancreatic ducts (PMID: 2410375). The radioactive isotope technetium-99m labelled version of this antibody is also called Besilesomab (trade name Scintimun). It has been studied widely for therapeutic applications. Technetium-99m-Labeled BW 250/183 was used to study the inflamatory process and identification of the inflamatory foci using immunoscintigraphy (PMID: 2157831, 1565572). This antibody is also used for scintiographic imaging of soft tissue infections, peripheral bone, and abdominal infections (PMID: 8023170). Tc-99m-labeled antibody has also been used in the localization of extramedullary hematopoiesis (PMID: 11953571). Rhenium-188-labelled BW250/183 was developed for adjuvant conditioning radioimmunotherapy of bone marrow before bone marrow transplantation. Immunoreactivity of the reduced and rhenium-incorporated antibody was determined by indirect immunofluorescence, by means of a whole blood staining method follwoed by flow ctometric analysis (PMID: 10541824). 90Y‐label is reportedled antibody is reported to be used in the study of expression of CD66b in non‐Hodgkin lymphomas and multiple myeloma usinf flow cytometry (PMID: 20887387).

Product Class:	Purified
Clone ID:	BW 250/183
Heavy Chain Modification:	Fc Silent™
Synonyms:	CEACAM8; CGM6; Carcinoembryonic antigen-related cell adhesion molecule 8; Carcinoembryonic antigen CGM6; CD67 antigen; Non-specific cross-reacting antigen; NCA-95
Amount:	200 μg
Application Codes Clone:	Immunoscintigraphy; Immunocytochemical staining; Therapeutic; IF; FC
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody binds the human CD66b, which is expressed on the surface of granulocytes.
Application Notes:	This murine antibody reacted with granulocytes, colon mucosa and faintly with pancreatic ducts (PMID: 2410375). The radioactive isotope technetium-99m labelled version of this antibody is also called Besilesomab (trade name Scintimun). It has been studied widely for therapeutic applications. Technetium-99m-Labeled BW 250/183 was used to study the inflamatory process and identification of the inflamatory foci using immunoscintigraphy (PMID: 2157831, 1565572). This antibody is also used for scintiographic imaging of soft tissue infections, peripheral bone, and abdominal infections (PMID: 8023170). Tc-99m-labeled antibody has also been used in the localization of extramedullary hematopoiesis (PMID: 11953571). Rhenium-188-labelled BW250/183 was developed for adjuvant conditioning radioimmunotherapy of bone marrow before bone marrow transplantation. Immunoreactivity of the reduced and rhenium-incorporated antibody was determined by indirect immunofluorescence, by means of a whole blood staining method follwoed by flow ctometric analysis (PMID: 10541824). 90Y‐label is reportedled antibody is reported to be used in the study of expression of CD66b in non‐Hodgkin lymphomas and multiple myeloma usinf flow cytometry (PMID: 20887387).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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