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Mfg Part Number

Ab02240-23.0

Vector Labs Ab02240-23.0 Anti-HPi2 [HIC1-2B4], Rabbit IgG, kappa (200 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated by immunizing BALB/c mice with endocrine cells of the islets of Langerhans.

$517.40

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Description

Product Class: Purified
Clone ID: HIC1-2B4
Synonyms: Human Pancreas Endocrine Islet Cell Marker 2; Human pancreatic marker; Endocrine pan-islet cell marker
Amount: 200 μg
Application Codes Clone: IHC; FC; IF
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody binds the HPi2 marker on the surface of human pancreatic enriched islet cells.
Application Notes: This antibody binds distinct surface molecules expressed on endocrine cells and have been validated for a number of experimental methods including immunohistochemistry and live cell sorting by flow cytometry. This antibody can be used individually or in combination with others to isolate populations of α, β, exocrine, or duct cells from primary human pancreas by FACS and to characterize the detailed cell composition of human islet preparations (PMID: 19383399, 27641999). This antibody was used in combination with HIC3-2D12 to identify and isolate major subtypes of the human islet cells including α- and β-cells and the purity levels of the isolated cells was determined using immunofluorescence staining (PMID: 31780397). Humanized version of this antibody has also been reported (PMID: 29758224). Chimeric antigen receptor (CAR) with scFv form of this antibody was used in the novel Tregs-based antigen-specific Type 1 Diabetes (T1D) immunotherapy (PMID: 33068914).

Product Class:	Purified
Clone ID:	HIC1-2B4
Synonyms:	Human Pancreas Endocrine Islet Cell Marker 2; Human pancreatic marker; Endocrine pan-islet cell marker
Amount:	200 μg
Application Codes Clone:	IHC; FC; IF
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody binds the HPi2 marker on the surface of human pancreatic enriched islet cells.
Application Notes:	This antibody binds distinct surface molecules expressed on endocrine cells and have been validated for a number of experimental methods including immunohistochemistry and live cell sorting by flow cytometry. This antibody can be used individually or in combination with others to isolate populations of α, β, exocrine, or duct cells from primary human pancreas by FACS and to characterize the detailed cell composition of human islet preparations (PMID: 19383399, 27641999). This antibody was used in combination with HIC3-2D12 to identify and isolate major subtypes of the human islet cells including α- and β-cells and the purity levels of the isolated cells was determined using immunofluorescence staining (PMID: 31780397). Humanized version of this antibody has also been reported (PMID: 29758224). Chimeric antigen receptor (CAR) with scFv form of this antibody was used in the novel Tregs-based antigen-specific Type 1 Diabetes (T1D) immunotherapy (PMID: 33068914).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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