Mfg Part Number
Ab02251-10.0
Vector Labs Ab02251-10.0 Anti-HCN1 [N70/28], Human IgG1, kappa (200 μg)
Quick Overview
This antibody was raised by immunising BALB/c mice with a fusion of protein amino acids 778-910 (cytoplasmic C-terminus) of rat HCN1.
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| Product Class: | Purified |
|---|---|
| Clone ID: | N70/28 |
| Synonyms: | N70/28R; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 |
| Amount: | 200 μg |
| Application Codes Clone: | IF; WB; IHC; ICC; immunogold labeling |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for the amino acids 778-910 of the HCN1 protein. HCN1 is a hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). |
| Application Notes: | This antibody was used in a immunoblotting experiment on mouse neural tissue (Arimitsu et al, 2009; PMID:19563776). Immunohistochemistry was preformed on forebrain tissue of mice using this antibody (Zhou et al, 2013; PMID:23377220). The ganglion tissue of CBA/CaJ mice was used in a immunocytochemistry experiment using this antibody (Liu et al, 2014; PMID:24558054). Immunogold labeling was preformed on coronal sections of the brain of mice using this antibody (Huang et al, 2017; PMID:28071723). This antibody was used in a immunoblotting experiment on rat retinal ganglion cells (Stradleigh et al, 2011; PMID:21456027). Immunofluorescence was preformed on the brain of mice using this antibody (Kole et al, 2015; PMID:26269648). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |