Mfg Part Number
Ab02255-10.3
Vector Labs Ab02255-10.3 Anti-Laforin [N84/37.1], Human IgG1, Fc Silent™, kappa (200 μg)
Quick Overview
This antibody was raised by immunising BALB/c mice with a fusion protein amino acids 1-331 (full-length) of human Laforin.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | N84/37.1 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | N84/37.1R; EPM2A; Glucan phosphatase; Glycogen phosphatase; Lafora PTPase; LAFPTPase |
| Amount: | 200 μg |
| Application Codes Clone: | WB; ICC; IHC; KO |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for the human laforin protein. Laforin plays an important role in preventing glycogen hyperphosphorylation and the formation of insoluble aggregates, via its activity as glycogen phosphatase, and by promoting the ubiquitination of proteins involved in glycogen metabolism via its interaction with the E3 ubiquitin ligase NHLRC1/malin. |
| Application Notes: | This antibody is recommended for detection and analysis of laforin by immunoblotting, immunocytochemistry, immunohistochemistry and knockout. For instance, the mouse version of this antibody was used to detect laforin by western blot in crude membrane fractions from whole rat or mouse brain and from human hippocampus, cerebral cortex or cerebellum. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |