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Mfg Part Number

Ab02260-10.3

Vector Labs Ab02260-10.3 Anti-GABA(B)R [N93A/49.2], Human IgG1, Fc Silent™, kappa (200 μg)

VECTOR LABS

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Quick Overview

This antibody was raised by immunising BALB/c mice with a fusion protein of amino acids 873-977 (cytoplasmic C-terminus) of rat GABABR1.

$517.40

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Description

Product Class: Purified
Clone ID: N93A/49.2
Heavy Chain Modification: Fc Silent™
Synonyms: N93A/49.2R; Gamma-aminobutyric acid type B receptor subunit 1; Gabbr1; GABA-B receptor 1; GABA-B-R1; GABA-BR1; GABABR1; Gb1
Amount: 200 μg
Application Codes Clone: PLA; IP; IF
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG2a
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody is specific for amino acids 873-977 (cytoplasmic C-terminus) of rat GABABR1. GABABR1 is a component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins.
Application Notes: This antibody was used in a proximity ligation assay on HEK293 cells transiently transfected using Lipofectamine 2000 with cDNA plasmids expressing GABABR1-eYFP, GABABR2 and GIRK2a (Li et al, 2020; PMID:32111696). Immunofluorescence was preformed on the hippocampal slices of P7 male Wistar rats using this antibody (Wright et al, 2017; PMID:28450542). An immunoprecipitation was preformed with this antibody on lysates from hippocampal slices of P7 male Wistar rats (Wright et al, 2017; PMID:28450542). Immunofluorescence was preformed on the brain of Tg(Gng3-GFP)- HK208Gsat and KI(Gng7-3-IRES-GFP) mice (Schwindinger et al, 2012; PMID:22207761).

Product Class:	Purified
Clone ID:	N93A/49.2
Heavy Chain Modification:	Fc Silent™
Synonyms:	N93A/49.2R; Gamma-aminobutyric acid type B receptor subunit 1; Gabbr1; GABA-B receptor 1; GABA-B-R1; GABA-BR1; GABABR1; Gb1
Amount:	200 μg
Application Codes Clone:	PLA; IP; IF
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG2a
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody is specific for amino acids 873-977 (cytoplasmic C-terminus) of rat GABABR1. GABABR1 is a component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins.
Application Notes:	This antibody was used in a proximity ligation assay on HEK293 cells transiently transfected using Lipofectamine 2000 with cDNA plasmids expressing GABABR1-eYFP, GABABR2 and GIRK2a (Li et al, 2020; PMID:32111696). Immunofluorescence was preformed on the hippocampal slices of P7 male Wistar rats using this antibody (Wright et al, 2017; PMID:28450542). An immunoprecipitation was preformed with this antibody on lysates from hippocampal slices of P7 male Wistar rats (Wright et al, 2017; PMID:28450542). Immunofluorescence was preformed on the brain of Tg(Gng3-GFP)- HK208Gsat and KI(Gng7-3-IRES-GFP) mice (Schwindinger et al, 2012; PMID:22207761).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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