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Mfg Part Number

Ab02310-10.0

Vector Labs Ab02310-10.0 Anti-Shank3 [N69/46R], Human IgG1, kappa (200 μg)

VECTOR LABS

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Quick Overview

This antibody was raised against synthetic peptide of amino acids 840-857 of rat Shank3.

$517.40

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Description

Product Class: Purified
Clone ID: N69/46R
Synonyms: SH3 and multiple ankyrin repeat domains protein 3; Proline-rich synapsee-associated protein 2; ProSAP2; SPANK-2; N69/46
Amount: 200 μg
Application Codes Clone: WB
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG2a
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody is specific for the shank3. It shows no cross-reactivity against Shank1 or Shank2. Shank3 is a major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapsee formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton.
Application Notes: This antibody was used for immunoblotting on hemibrains of wild-type, heterozygous and homozygous Shank3 mice (Bozdagi et al, 2010; PMID:21167025). hemibrains of wild-type, heterozygous and homozygous Shank3 rats were used for immunoblotting with this antibody (Harony-Nicolas et al, 2017; PMID:28139198). Half brains of mice were immunoblotted with this antibody (Kolevzon et al, 2010; PMID:21062623). Western blotting was preformed with this antibody on mouse tissue (Nikoletopoulou et al, 2017; PMID:28683289).

Product Class:	Purified
Clone ID:	N69/46R
Synonyms:	SH3 and multiple ankyrin repeat domains protein 3; Proline-rich synapsee-associated protein 2; ProSAP2; SPANK-2; N69/46
Amount:	200 μg
Application Codes Clone:	WB
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG2a
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody is specific for the shank3. It shows no cross-reactivity against Shank1 or Shank2. Shank3 is a major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapsee formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton.
Application Notes:	This antibody was used for immunoblotting on hemibrains of wild-type, heterozygous and homozygous Shank3 mice (Bozdagi et al, 2010; PMID:21167025). hemibrains of wild-type, heterozygous and homozygous Shank3 rats were used for immunoblotting with this antibody (Harony-Nicolas et al, 2017; PMID:28139198). Half brains of mice were immunoblotted with this antibody (Kolevzon et al, 2010; PMID:21062623). Western blotting was preformed with this antibody on mouse tissue (Nikoletopoulou et al, 2017; PMID:28683289).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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