Mfg Part Number
Ab02313-10.3
Vector Labs Ab02313-10.3 Anti-Mad3 [N129A/6R], Human IgG1, Fc Silent™, kappa (200 μg)
Quick Overview
This antibody was raised against a fusion protein of amino acids 116-206 of human Mad3.
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| Product Class: | Purified |
|---|---|
| Clone ID: | N129A/6R |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta; MAD3/BUB1-related protein kinase; hBUBR1; Mitotic checkpoint kinase MAD3L; Protein SSK1; N129A/6 |
| Amount: | 200 μg |
| Application Codes Clone: | ICC; WB |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for Mad3. Mad3 is an essential component of the mitotic checkpoint. It is required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. |
| Application Notes: | This antibody is recommended for detection and analysis of Mad3 by Immunocytochemistry and western blot. For instance, the mouse version of this antibody was used to detect Mad3 by western blot in extracts of COS cells transiently transfected with HA-tagged mouse and human Mad3 (mMad3 and hMad3, respectively) and untagged Kv2.1 plasmids. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |