Vector Labs Ab02324-8.4 Anti-Kv2.1 K+ channel pS603 [L61/14R], Rat IgG2b, Fc Silent™, kappa (200 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: L61/14R
Heavy Chain Modification: Fc Silent™
Synonyms: Potassium voltage-gated channel subfamily B member 1; Kcnb1; Delayed rectifier potassium channel 1; DRK1; Voltage-gated potassium channel subunit Kv2.1
Amount: 200 μg
Application Codes Clone: WB; IHC; ELISA; IF
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG2a
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric rat antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody is specific for Kv2.1. Kv2.1 is a voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain.
Application Notes: Immunoblotting was preformed on Kv2.1-KO and AMIGO-KO mouse brain samples (Mandikian et al, 2014; PMID:24962901). immunohistochemistry against brain samples from wild-type mice subjected to CO2 inhalation was preformed with this antibody (Mandikian et al, 2014; PMID:24962901). This antibody was validated with ELISA on rat Kv2.1 amino acids 595–616 (Mandikian et al, 2014; PMID:24962901). COS-1 and CHO cells expressing Kv channels were used for immunofluorescence with this antibody (Cobb et al, 2015; PMID:26442584). COS-1 and CHO cell lysates transfected with transfected with rat Kv2.1, Kv1.4, or Kv2.1 were immunoblotted with this antibody (Cobb et al, 2015; PMID:26442584).

Product Class:	Purified
Clone ID:	L61/14R
Heavy Chain Modification:	Fc Silent™
Synonyms:	Potassium voltage-gated channel subfamily B member 1; Kcnb1; Delayed rectifier potassium channel 1; DRK1; Voltage-gated potassium channel subunit Kv2.1
Amount:	200 μg
Application Codes Clone:	WB; IHC; ELISA; IF
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG2a
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric rat antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody is specific for Kv2.1. Kv2.1 is a voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain.
Application Notes:	Immunoblotting was preformed on Kv2.1-KO and AMIGO-KO mouse brain samples (Mandikian et al, 2014; PMID:24962901). immunohistochemistry against brain samples from wild-type mice subjected to CO2 inhalation was preformed with this antibody (Mandikian et al, 2014; PMID:24962901). This antibody was validated with ELISA on rat Kv2.1 amino acids 595–616 (Mandikian et al, 2014; PMID:24962901). COS-1 and CHO cells expressing Kv channels were used for immunofluorescence with this antibody (Cobb et al, 2015; PMID:26442584). COS-1 and CHO cell lysates transfected with transfected with rat Kv2.1, Kv1.4, or Kv2.1 were immunoblotted with this antibody (Cobb et al, 2015; PMID:26442584).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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