Vector Labs Ab02329-10.3 Anti-CD4 [6G5 (Zanolimumab)], Human IgG1, Fc Silent™, kappa (200 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: 6G5 (Zanolimumab)
Heavy Chain Modification: Fc Silent™
Synonyms: Lu/T4; T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3
Amount: 200 μg
Application Codes Clone: ELISA, FC, Inhibit,
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Specificity Statement: This antibody binds human CD4.
Application Notes: Zanolimumab (clone 6G5, HuMax-CD4, MDX CD4, MDX-016) was among the first fully human mAbs generated from human Ig transgenic mice. The antigen specificity of this antibody was determined using ELISA (PMID: 9631008). The mAb 6G5 was subsequently re-expressed in CHO cells without altering its binding or functional characteristics and renamed HM6G. The avidity of 6G5 for native CD4 expressed on human and nonhuman primate lymphocytes was examined in a flow cytometry assay (PMID: 10444358). Zanolimumab inhibitsCD4+T cells by combining signaling inhibition with potent induction of Fc-mediated effector functions. T cell activation is inhibited by a fast dual mechanism in which the antibody abrogates signaling via the T cell receptor (TCR) and, in addition, down regulates T cell activation by transmission of direct inhibitory signals. In addition, zanolimumab induces killing of CD4+ T cells via antibody-dependent cellular cytotoxicity (PMID: 17942927). Zanolimumab exhibits cytotoxic and anti-proliferative effects and has shown efficacy in T-cell lymphomas. A clinical efficacy and safety study of treatment with weekly dose of 980 mg of HuMax-CD4 in 8 patients having refractory or relapsed CD4+ peripheral T-cell lymphoma (PTCL) of non-cutaneous type revealed that Zanolimumab is well tolerated (PMID: 20629661). Zanolimumab has also been reported to cause depletion of CD4+ T cells from human skin in a human psoriasis xenograft mouse model (PMID: 17091277).

Product Class:	Purified
Clone ID:	6G5 (Zanolimumab)
Heavy Chain Modification:	Fc Silent™
Synonyms:	Lu/T4; T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3
Amount:	200 μg
Application Codes Clone:	ELISA, FC, Inhibit,
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Specificity Statement:	This antibody binds human CD4.
Application Notes:	Zanolimumab (clone 6G5, HuMax-CD4, MDX CD4, MDX-016) was among the first fully human mAbs generated from human Ig transgenic mice. The antigen specificity of this antibody was determined using ELISA (PMID: 9631008). The mAb 6G5 was subsequently re-expressed in CHO cells without altering its binding or functional characteristics and renamed HM6G. The avidity of 6G5 for native CD4 expressed on human and nonhuman primate lymphocytes was examined in a flow cytometry assay (PMID: 10444358). Zanolimumab inhibitsCD4+T cells by combining signaling inhibition with potent induction of Fc-mediated effector functions. T cell activation is inhibited by a fast dual mechanism in which the antibody abrogates signaling via the T cell receptor (TCR) and, in addition, down regulates T cell activation by transmission of direct inhibitory signals. In addition, zanolimumab induces killing of CD4+ T cells via antibody-dependent cellular cytotoxicity (PMID: 17942927). Zanolimumab exhibits cytotoxic and anti-proliferative effects and has shown efficacy in T-cell lymphomas. A clinical efficacy and safety study of treatment with weekly dose of 980 mg of HuMax-CD4 in 8 patients having refractory or relapsed CD4+ peripheral T-cell lymphoma (PTCL) of non-cutaneous type revealed that Zanolimumab is well tolerated (PMID: 20629661). Zanolimumab has also been reported to cause depletion of CD4+ T cells from human skin in a human psoriasis xenograft mouse model (PMID: 17091277).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

Reviews