Mfg Part Number
Ab02348-23.0
Vector Labs Ab02348-23.0 Anti-HIV-1 GP120 [YZ18], Rabbit IgG, kappa (200 μg)
Quick Overview
The original antibody was generated by immunizing mice with an electrophilic HIV-1 gp120 covalently reactive analog (E-gp120).
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| Product Class: | Purified |
|---|---|
| Clone ID: | YZ18 |
| Synonyms: | Glycoprotein 120; SU; surface protein gp120; env polyprotein; envelope glycoprotein gp16 |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA, NTRL |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody binds irreversibly with GP120 of the HIV-1 virus. This antibody shows specific binary reactivity for peptides containing amino acid residues 292–306 and 421– 433 of the gp120 protein. |
| Application Notes: | This antibody is capable of irreversibly binding both HIV-1 GP120 and its covalently reactive analogue in an ELISA. It is reported that this antibody is capable of slowly cleaving biotinylated gp120 (Lys residues are labelled with biotin) (PMID: 12665517). This antibody neutralized the infection of peripheral blood mononuclear cells by a primary HIV-1 isolate belonging to clade C (strain ZA009) (PMID: 16838382). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |