Mfg Part Number
Ab02396-10.3
Vector Labs Ab02396-10.3 Anti-CXCR4 [I-3859 ], Human IgG1, Fc Silent™, kappa (200 μg)
Quick Overview
The original antibody was generated by immunizing BALB/c mice with recombinant NIH3T3-CXCR4 cells and/or peptides corresponding to CXCR4 extracellular N-term and loops.
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| Product Class: | Purified |
|---|---|
| Clone ID: | I-3859 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | CD184; CXC-R4; CXCR-4; FB22; Fusin; HM89; LCR1; LESTR; LAP-3; C-X-C chemokine receptor type 4; Leukocyte-derived seven transmembrane domain receptor; Lipopolysaccharide-associated protein 3; LPS-associated protein 3; NPYRL; Stromal cell-derived factor 1 receptor; SDF-1 receptor |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; IP; FC; IHC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody binds the human CXCR4. |
| Application Notes: | The binding of this antibody to human CXCR4 was tested using ELISA. This antibody is capable of immunoprecipitating both CXCR4 monomers and dimers. I-3859 can also recognize CXCR4 present on NIH3T3-hCXCR4 transfected cells, MDA-MB-231,U937 promyelocytic cancer cells and Hela cervix cancer cells by flow cytometry. This antibody is also found to compete with other Anti-CXCR4 mAb 515H7 for binding to cell membrance as analyzed by flow cytometry. This antibody can be used for the immunohistochemical staining of tumor cells expressing CXCR4. It was used for the staining of RAMOS and KARPAS299 xenograft tumor cells (US20140170677). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |