Mfg Part Number
Ab02401-10.3
Vector Labs Ab02401-10.3 Anti-iC3b [6G1], Human IgG1, Fc Silent™, kappa (200 μg)
Quick Overview
The original antibody was generated by immunizing mice intraperitoneally with human iC3b protein mixed with RIBI adjuvant.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | 6G1 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | inactivated C3b; Complement C3; C3; Complement C3 beta chain |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; IP; IHC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody recognizes a conformational epitope on the human iC3b. |
| Application Notes: | This antibody binds iC3b with a dissociation constant of 43.3 nM. This antibody can be used in combination with 5D2 to detect iC3b in a sanwich ELISA. This antibody was used to identify iC3b using immunoprecipitation. This antbody was also used for the immunohistochemical analysis of Alzheimer's disease brain and was successful in labelling plaques with various morphologies in the grey matter at a 0.625 μg/mL dilution. This antibody can successfully stain human bruch's membrane/choroid tissues samples from patients having age related macular degeneration (AMD). It was able to identify drusen associated with bruch's membrane in stage 3 and 4 AMD tissues (US20140127225). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |