Mfg Part Number
Ab02407-10.3
Vector Labs Ab02407-10.3 Anti-Notch 1 [2E6], Human IgG1, Fc Silent™, kappa (200 μg)
Quick Overview
The original antibody was generated by immunizing BALB/c mice with a concatemeric protein containing 4 repeats of amino acids 413-488 of human Notch 1 linked by two non-Notch 1 amino acids (AG linker).
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| Product Class: | Purified |
|---|---|
| Clone ID: | 2E6 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | Notch1; hN1; TAN-1; Neurogenic locus notch homolog protein 1; Translocation-associated notch protein TAN-1 |
| Amount: | 200 μg |
| Application Codes Clone: | Inhibit; Block |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody binds human notch 1. |
| Application Notes: | The original human IgG1 version of this antagonist antibody binds notch 1 with an affinity of Kd= 8 nM. This antibody is capable of efficiently blocking the binding of all 4 ligands (Jag1, Jag2, DLL1 and DLL4) to notch 1. This antibody was also capable of specifically inhibiting Notch 1-dependent transcription. In vivo, this antibody was found to show little to no intestinal toxicity in mice. Hu2E6-62 caused decrease in functional angiogenesis by increasing vascular branching and decreasing vascular function. It inhibited angiogenesis induced by the human lung cancer Calu-6 cells. This antibody can be used to inhibit or reduced the proliferation and growth of tumors (WO2012003472). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |