Mfg Part Number
Ab02408-23.0
Vector Labs Ab02408-23.0 Anti-Notch 3 [hN3S2-160], Rabbit IgG, lambda (200 μg)
Quick Overview
The original antibody was isolated from an scFv phage display library generated from BMV (bone marrow), CS (spleen) and DP47 (frame work based CS) and by panning against a fusion protein containing Notch3 extracellular fragment (amino acid 40-467) and human IgG1-Fc.
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| Product Class: | Purified |
|---|---|
| Clone ID: | hN3S2-160 |
| Synonyms: | Neurogenic locus notch homolog protein 3 |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; FC; |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This full-length, chimeric rabbit antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody binds human notch 3. |
| Application Notes: | The original human IgG1 antibody hN3S2-160 binds notch 3 with an EC50 =0.06 nM. The binding affinity of this antibody for notch 3 was determined using ELISA. The binding of hN3S2-160 to notch 3 on 293 Flp-TRex cells was done using flow cytometry. This antibody is also capable of blocking notch 3 and DLL4 ligand interaction (WO2010141249). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |