Mfg Part Number
Ab02460-10.3
Vector Labs Ab02460-10.3 Anti-HER3 [A5 ], Human IgG1, Fc Silent™, lambda (200 μg)
Quick Overview
The original antibody was created using phage display from large naïve human scFv libraries.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | A5 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | ERBB3; Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3; HER3.A5 |
| Amount: | 200 μg |
| Application Codes Clone: | SPR; FC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | scFv |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This full-length, reformatted human antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for HER3. |
| Application Notes: | A5 scFv binds to ErbB3 ECD with a KD of 1.6 × 10−7 M. The ability to bind HER3 was assesed in this antibody using surface plasmon resonance. An anti ErbB2/ErbB3 bispecific antibody made from ML3-9 and A5 clones called the A5-linker-ML3.9 bs-scFv exhibits selective targeting of tumour cells in vitro and in vivo that co-express the two target antigens over tumour cells that express only one target antigen or normal cells that express low levels of both antigens. This study was done using flow cytometry. (Robinson et al, 2008;pmid:18841159). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |