Mfg Part Number
Ab02462-30.11-BS
Vector Labs Ab02462-30.11-BS Anti-HER2 [ML3-9 (C6ML3-9)], scFv fragment (His), ScFv, (1 mg)
Quick Overview
The original antibody was created using phage display from large naïve human scFv libraries.
$4,938.70
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | ML3-9 (C6ML3-9) |
| Heavy Chain Modification: | ScFv |
| Synonyms: | CD340; ERBB2; MLN 1; NEU; NGL; Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; p185HER2; ML3.9; C6ML3.9 |
| Amount: | 1 mg |
| Application Codes Clone: | RIA; SPR; FC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS only. |
| Original Format: | scFv |
| Storage Temperature: | Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody is specific for HER2. |
| Application Notes: | This antibody is an affinity matured version of the parent scFv antibody C6.5 (Schier et al,1996;pmid: 8918938). The ML3-9 scFv binds to the ErbB2 ECD with a KD of 1.1 nM. Another clone derived from ML3-9 An radioimmunoassay was performed on human serum using this antibody. The ability to bind HER2/neu was assesed in this antibody using surface plasmon resonance. An anti ErbB2/ErbB3 bispecific antibody made from ML3-9 and A5 clones called the A5-linker-ML3.9 bs-scFv exhibits selective targeting of tumour cells in vitro and in vivo that co-express the two target antigens over tumour cells that express only one target antigen or normal cells that express low levels of both antigens. This study was done using flow cytometry (Robinson et al, 2008;pmid:18841159). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |