Mfg Part Number
Ab02488-10.3
Vector Labs Ab02488-10.3 Anti-EphA3 [KB004], Human IgG1, Fc Silent™, kappa (200 μg)
Quick Overview
This antibody was created by humanizing the IIIA4 antibody. The IIIA4 antibody was raised by immunizing mice with LK63 cells.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | KB004 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | Ephrin type-A receptor 3; EPH-like kinase 4; EK4; hEK4; HEK; Human embryo kinase; Tyrosine-protein kinase TYRO4; Tyrosine-protein kinase receptor ETK1; Eph-like tyrosine kinase 1 |
| Amount: | 200 μg |
| Application Codes Clone: | therapeutic; functional assay |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for human epha3 receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. |
| Application Notes: | This antibody has been shown to have a wide therapeutic potential. Human version of this antibody was shown to be safe for treatment of patients with refractory hematologic malignancies (Swords et al, 2016; pmid:27736729). Further, it has been shown that this antibody was cytotoxic to LK63 cell lines (Charmsaz et al, 2017; pmid:27922598). Besides this, the antibody was also shown to reduce multiple myeloma angiogenesis (Caivano et al, 2017; pmid:28415715). Fianlly, this antibody has been observed to reduice lung fibrosis is mice (WO2018053032). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |