Mfg Part Number
Ab02491-23.0
Vector Labs Ab02491-23.0 Anti-VEGFR2 [V2], Rabbit IgG, kappa (200 μg)
Quick Overview
The original human version of this antibody was created by screening a human phage display library with VEGFR2-Fc.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | V2 |
| Synonyms: | Vascular endothelial growth factor receptor 2; KDR; VEGFR-2; Fetal liver kinase 1; FLK-1; Kinase insert domain receptor; Protein-tyrosine kinase receptor flk-1; CD309 |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; FC; functional assay |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for the VEGFR2 protein. It shows no binding to individual domains 2-3, 1-3 and 1-4. VEGFR2 is a tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. It plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. |
| Application Notes: | The human version of this antibody was tested by ELISA with different domains of VEGFR2 (WO2017004254). Furthermore, binding of the human version of this antibody to human umbilical vein endothelial cells was demostrated using flow cytometry (WO2017004254). After that, HUVEC tube formation assays were preformed using the human version of this antibody. This antibody did not show significant inhibition of tube formation (WO2017004254). Further, a matrigel plug assay was preformed using the human version of this antibody to asses its ability to inhibit angiogenesis in vivo (WO2017004254). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |