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Mfg Part Number

Ab02559-23.0

Vector Labs Ab02559-23.0 Anti-CTLA4 [1B8], Rabbit IgG, kappa (200 μg)

VECTOR LABS

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Quick Overview

The antibody was generated by immunizing Armenian hamsters with the extracellular portion of murine CTLA-4 fused to a murine IgG2.

$517.40

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Description

Product Class: Purified
Clone ID: 1B8
Synonyms: Cytotoxic T-lymphocyte protein 4; Ctla4; Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD152; UC10-4FIO
Amount: 200 μg
Application Codes Clone: ELISA; FC; IF; WB; blocking
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Hamster IgG format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody is specific for CTLA-4. CTLA-4 is an inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
Application Notes: ELISA was preformed on murine CTLA-4lg to test the binding specificity of the anitbody (Walunas et al, 1994; pmid:7882171). For flow cytometry on A20, M12.41 (B cells), L cell (fibroblast), and P815 (mastocytoma) cells this antibody was used (Perkins et al, 1996; pmid:8666782). This antibody was used for blocking in mice. It prevented T-cell proliferation (Leach et al, 1996; pmid:8596936). Western blot was preformed on LN cells harvested from SJL mice using this antibody (Aruna et al, 2005; pmid:16014414). This antibody was used for flow cytometry on LN cells harvested from SJL mice (Aruna et al, 2005; pmid:16014414). Mouse CD4+ CD25+ T cells were used for a flow cytomic experiment using this antibody (Valsazina et al, 2006; pmid:16618776). Thymi from Tg4 CTLA-4WT and B10.PL

Product Class:	Purified
Clone ID:	1B8
Synonyms:	Cytotoxic T-lymphocyte protein 4; Ctla4; Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD152; UC10-4FIO
Amount:	200 μg
Application Codes Clone:	ELISA; FC; IF; WB; blocking
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric rabbit antibody was made using the variable domain sequences of the original Hamster IgG format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody is specific for CTLA-4. CTLA-4 is an inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
Application Notes:	ELISA was preformed on murine CTLA-4lg to test the binding specificity of the anitbody (Walunas et al, 1994; pmid:7882171). For flow cytometry on A20, M12.41 (B cells), L cell (fibroblast), and P815 (mastocytoma) cells this antibody was used (Perkins et al, 1996; pmid:8666782). This antibody was used for blocking in mice. It prevented T-cell proliferation (Leach et al, 1996; pmid:8596936). Western blot was preformed on LN cells harvested from SJL mice using this antibody (Aruna et al, 2005; pmid:16014414). This antibody was used for flow cytometry on LN cells harvested from SJL mice (Aruna et al, 2005; pmid:16014414). Mouse CD4+ CD25+ T cells were used for a flow cytomic experiment using this antibody (Valsazina et al, 2006; pmid:16618776). Thymi from Tg4 CTLA-4WT and B10.PL

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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