Mfg Part Number
Ab02568-23.0
Vector Labs Ab02568-23.0 Anti-estrogen receptor beta [CO1531], Rabbit IgG, kappa (200 μg)
Quick Overview
This antibody was raised by immunizing a rat with human estrogen protein.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | CO1531 |
| Synonyms: | Estrogen receptor beta; ESR2; ER-beta; Nuclear receptor subfamily 3 group A member 2 |
| Amount: | 200 μg |
| Application Codes Clone: | WB; IP |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for human estrogen receptor. The estrogen receptor is a nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. |
| Application Notes: | The antibody was used for western blot on tissues of C57BL/6J wild-type mice (Montani et al, 2008; pmid:18281260). Whole-cell extracts from cells expressing ERα-LBD or full-length ERβ were immunoprecipitated with this antibody (Leong et al, 2005; pmid:16051668). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |