JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

Skip to the beginning of the images gallery

Mfg Part Number

Ab02622-10.3

Vector Labs Ab02622-10.3 Anti-TrkB.T1 [FH1D12], Human IgG1, Fc Silent™, kappa (200 μg)

VECTOR LABS

Be the first to review this product

Quick Overview

This antibody was raised by immunizing male and female 20-week-old C57BL6 mice that were characterized as genetic null for TrkB.T1 with TrkB.T1 peptide Ac-C(dPEG4)FVLFHKIPLDG-OH maleimide coupled to KLH carrier protein.

$517.40

Order will ship within 1-3 business days

Description

Product Class: Purified
Clone ID: FH1D12
Heavy Chain Modification: Fc Silent™
Synonyms: BDNF/NT-3 growth factors receptor; NTRK2; GP145-TrkB; Trk-B; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Tropomyosin-related kinase B
Amount: 200 μg
Application Codes Clone: IHC; WB; FC
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG2b
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody is specific for TrkB.T1 peptide Ac-C(dPEG4)FVLFHKIPLDG. TrkB.T1 is a receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity.
Application Notes: To validate this antibody, immunohistochemistry was preformed on multi-tissue block containing human brain, mouse brain, TrkB.T1−/− mouse brain, a cell pellet over-expressing TrkB.T1 and a cell pellet without TrkB.T1 were stained using the scFv version of this antibody. Furthermore, the specificity of this antibody was proven using western blot with the mouse version of this clone. Finally, flow cytometry confirmed the specificity of the mouse version of this antibody (Patwell et al, 2020; pmid:32532995).

Product Class:	Purified
Clone ID:	FH1D12
Heavy Chain Modification:	Fc Silent™
Synonyms:	BDNF/NT-3 growth factors receptor; NTRK2; GP145-TrkB; Trk-B; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Tropomyosin-related kinase B
Amount:	200 μg
Application Codes Clone:	IHC; WB; FC
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG2b
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody is specific for TrkB.T1 peptide Ac-C(dPEG4)FVLFHKIPLDG. TrkB.T1 is a receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity.
Application Notes:	To validate this antibody, immunohistochemistry was preformed on multi-tissue block containing human brain, mouse brain, TrkB.T1−/− mouse brain, a cell pellet over-expressing TrkB.T1 and a cell pellet without TrkB.T1 were stained using the scFv version of this antibody. Furthermore, the specificity of this antibody was proven using western blot with the mouse version of this clone. Finally, flow cytometry confirmed the specificity of the mouse version of this antibody (Patwell et al, 2020; pmid:32532995).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

Reviews