Mfg Part Number
Ab02629-10.0
Vector Labs Ab02629-10.0 Anti-Notch3 [7G7-B10-H3], Human IgG1, kappa (200 μg)
Quick Overview
The original mouse version of this antibody was raised by immunizing a mouse with human notch 3.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | 7G7-B10-H3 |
| Synonyms: | Notch 3 extracellular truncation; Notch 3 intracellular domain; Neurogenic locus notch homolog protein 3 |
| Amount: | 200 μg |
| Application Codes Clone: | WB; functional assay |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for amino acids 807-884 of human notch3. Notch 3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). |
| Application Notes: | The original mouse version of this antibody is suitable for western blot. The mouse version of this antibody has also shown anti-proliferate activities in cancer cells in vitro. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |