Mfg Part Number
Ab02636-10.0
Vector Labs Ab02636-10.0 Anti-ZIKV EDII [G9E], Human IgG1, lambda (200 μg)
Quick Overview
This antibody was generated using 6XL method (Kwakkenbos et al., 2010). Memory B cells were isolated from a subject previously infected with ZIKV. After identification of ZIKV-specific monoclonal cultures, genetic material of the variable domains was isolated and recombinant IgG1 lambda antibody forms were grafted with the sequences.
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| Product Class: | Purified |
|---|---|
| Clone ID: | G9E |
| Synonyms: | Zika envelope protein DII; ZIKV; Zika virus EDII; EDII |
| Amount: | 200 μg |
| Application Codes Clone: | neutralizing; WB; ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody binds to ZIKV and does not cross-react with DENV4, which was tested as a representative DENV serotype. Its epitope is distinct from the A9E anti-ZIKV antibody. |
| Application Notes: | This antibody has very strong neutralizing properties against Asian and African lineages of ZIKV (Collins et al., 2019). Furthermore, this antibody was effective in preventing Zika infection when administered from one day before the infections in mice (Collins et al., 2019). Therefore, A9E is recommended in development of diagnostic assays which differentiate ZIKV from other flaviviruses (it does not crossreact with DENV) and in the development of therapeutics and vaccines against ZIKV. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |