Mfg Part Number
Ab02649-10.3
Vector Labs Ab02649-10.3 Anti-BR3 [V3-46s], Human IgG1, Fc Silent™, kappa (200 μg)
Quick Overview
The original antibody was generated from a synthetic antibody library that was built on a single human framework by introducing synthetic diversity at solvent-exposed positions within the heavy chain complementarity-determining regions.
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| Product Class: | Purified |
|---|---|
| Clone ID: | V3-46s |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | Tumor necrosis factor receptor superfamily member 13C; TNFRSF13C; B-cell-activating factor receptor; BAFF receptor; BAFF-R; BLyS receptor 3; CD268 |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; Blocking |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | Fab |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This reformatted human antibody was made using the variable domain sequences of the original Human Fab format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for the BR3 protein. |
| Application Notes: | This antibody was used for ELISA on mBR3-ECD and hBR3-ECD (US20080181888). This antibody blocks BAFF-BR3 binding (US20080181888). The Fab version of this antibody bound mouse BR3-ECD and human BR3-ECD with an affinity of 1nM and 0.6nM respectively. Humanized V3-46s antibody also blocked BAFF binding to BR3 on BJAB cells and bound BR3 on BJAB cells. This antibody was used as a template to make homolog shotgun libraries (US20080181888). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |