Vector Labs Ab02663-23.0 Anti-PSMA [7F12], Rabbit IgG, kappa (200 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: 7F12
Synonyms: PSM; FOLH1; FOLH; FGCP; GCPII; mGCP; NAALAD1; GIG27; Prostate specific membrane antigen; Glutamate carboxypeptidase 2; Cell growth-inhibiting gene 27 protein; Folate hydrolase 1; Folylpoly-gamma-glutamate carboxypeptidase; Glutamate carboxypeptidase II; Membrane glutamate carboxypeptidase; N-acetylated-alpha-linked acidic dipeptidase I; NAALADase I; Prostate-specific membrane antigen; Pteroylpoly-gamma-glutamate carboxypeptidase
Amount: 200 μg
Application Codes Clone: ELISA; IP
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody binds a conformational epitope on the human PSMA. This antibody can bind native PSMA protein but were unreactive with any fusion protein containing a portion of the PSMA sequence. Heat denaturation of PSMA also results in loss of binding.
Application Notes: This antibody was capable of detecting membrane fractions from human prostatic adenocarcinoma LNCaP and PC3 cells in a solid phase ELISA. This antibody was used for immunoprecipitation of PSMA from LNCaP cell detergent lysates. Antibody binding competition assays were done using flow cytometry and it revealed that 7F12 binds an epitope closed to another murine anti-PSMA antibody 3C6. This antibody was shown to mediated antibody dependent cellular cytotoxicity in human prostatic adenocarcinoma LNCaP cell targets with PBMC's from two donors (WO2003064606). This antibody was also used in the treatment of in vivo tumor xenografts with a combination of Taxotere® (US20090297438).

Product Class:	Purified
Clone ID:	7F12
Synonyms:	PSM; FOLH1; FOLH; FGCP; GCPII; mGCP; NAALAD1; GIG27; Prostate specific membrane antigen; Glutamate carboxypeptidase 2; Cell growth-inhibiting gene 27 protein; Folate hydrolase 1; Folylpoly-gamma-glutamate carboxypeptidase; Glutamate carboxypeptidase II; Membrane glutamate carboxypeptidase; N-acetylated-alpha-linked acidic dipeptidase I; NAALADase I; Prostate-specific membrane antigen; Pteroylpoly-gamma-glutamate carboxypeptidase
Amount:	200 μg
Application Codes Clone:	ELISA; IP
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody binds a conformational epitope on the human PSMA. This antibody can bind native PSMA protein but were unreactive with any fusion protein containing a portion of the PSMA sequence. Heat denaturation of PSMA also results in loss of binding.
Application Notes:	This antibody was capable of detecting membrane fractions from human prostatic adenocarcinoma LNCaP and PC3 cells in a solid phase ELISA. This antibody was used for immunoprecipitation of PSMA from LNCaP cell detergent lysates. Antibody binding competition assays were done using flow cytometry and it revealed that 7F12 binds an epitope closed to another murine anti-PSMA antibody 3C6. This antibody was shown to mediated antibody dependent cellular cytotoxicity in human prostatic adenocarcinoma LNCaP cell targets with PBMC's from two donors (WO2003064606). This antibody was also used in the treatment of in vivo tumor xenografts with a combination of Taxotere® (US20090297438).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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