Mfg Part Number
Ab02672-1.1
Vector Labs Ab02672-1.1 Anti-CD127 [GR34], Mouse IgG1, kappa (200 μg)
Quick Overview
The original parental clone was generated by immunizing BALB/c mice with Pre-Alp, a t(l;19) pre-B leukemic cell line.
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| Product Class: | Purified |
|---|---|
| Clone ID: | GR34 |
| Synonyms: | IL7R; IL7Rα; IL-7Rα; Interleukin-7 receptor subunit alpha; IL-7 receptor subunit alpha; IL-7R-alpha; IL-7RA; CDw127 |
| Amount: | 200 μg |
| Application Codes Clone: | antagonist; ELISA; block |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody binds human IL-7R. |
| Application Notes: | This IL-7R antagonist antibody is a recombinant engineered version of clone R34.34. The binding affinity of this antibody for human IL-7R was checked using ELISA. Antibody GR34 (mouse IgG1 version) was determined to inhibit pSTAT5 signalling with an IC50of 0.22μg/ml. The mouse IgG1 version had an affinity for the IL-7Rα EDC of 15.3nM (KD) and a Kd of 8.75X10-4. The mouse IgG1 version was capable of binding to IL-7Rα expressed on CHO cells with an EC50 of 0.27μg/ml, and blocked IL-7/IL-7Rα with an IC50of 2.29μg/ml (WO2010017468). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |