Mfg Part Number
Ab02723-23.0
Vector Labs Ab02723-23.0 Anti-HCV envelope glycoprotein E2 [AR3A ], Rabbit IgG, kappa (200 μg)
Quick Overview
The originala antibody was isolated from a phage-display library generated from a donor chronically infected with HCV.
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| Product Class: | Purified |
|---|---|
| Clone ID: | AR3A |
| Synonyms: | E2; Genome polyprotein; Envelope glycoprotein E2; NS1; gp68; gp70 |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; neutralize; immunotherapy; IP |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for the HCV E2 gylcoprotein. This antibody can recognize soluble E2 and native folded E2 glycoprotein but not reduced or denatured protein. |
| Application Notes: | This broadly neutralizing anitbody binds the AR3 antigenic regions of the HCV envelope glycoprotein and is capable of neutralizing JFH-1, H77, H, OH8, UKN1 B12.16, J6, UKN2 A1.2, UKN2 B1.1, UKN4. 21.16, UKN5. 15.7 strains of HCV (PMID: 18064037, 22492964). The IgG1 version of AR3A inhibited the binding of E1-E2 complex to the virus co-receptor CD81 at nanomolar concentration suggesting that this antibody can block HCV interaction with CD81 and thereby inhibit infection. The binding specificity of this antibody for E2 glycoprotein was determined using ELISA. AR3A provided protective immunity in two out of five mice receiving the antibody. This (PMID:18064037). This antibody was used for the immunoprecipitation of E2 glycoprotien cell lysates (PMID: 18355410). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |