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Mfg Part Number

Ab02759-10.3

Vector Labs Ab02759-10.3 Anti-Estrogen receptor [S72 (scFv7)], Human IgG1, Fc Silent™, lambda (200 μg)

VECTOR LABS

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Quick Overview

This antibody was generated from a phage display library constructed from normal human lymph cells using scFv expression vectors. The scFv antibody was isolated by panning the library against a target peptide comprising amino acid residues 284-310 of human estrogen receptor (hER-α36).

$517.40

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Description

Product Class: Purified
Clone ID: S72 (scFv7)
Heavy Chain Modification: Fc Silent™
Synonyms: ER; ERα36; hER-α36; ESR1; ER-alpha; NR3A1; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1
Amount: 200 μg
Application Codes Clone: ELISA; WB; therapeutic
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: scFv
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This full-length, reformatted human antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody is specific for the amino acid residues 284-310 of human estrogen receptor (hER-α36). The estrogen receptor is a nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling.
Application Notes: To characterize the binding of this antibody an ELISA was performed against biotinylated ERα36 using the scFv version. The scFv version of this antibody can also recognize human ERα36 in a western blot assay. And to identify the therapeutic advantages of this antibody, BCAP-37 tumors were implanted in balb/c nude mice after which the scFv version of this antibody was administered. The tumor sizes showed a significant difference with the control group (US20110311517).

Product Class:	Purified
Clone ID:	S72 (scFv7)
Heavy Chain Modification:	Fc Silent™
Synonyms:	ER; ERα36; hER-α36; ESR1; ER-alpha; NR3A1; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1
Amount:	200 μg
Application Codes Clone:	ELISA; WB; therapeutic
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	scFv
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This full-length, reformatted human antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody is specific for the amino acid residues 284-310 of human estrogen receptor (hER-α36). The estrogen receptor is a nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling.
Application Notes:	To characterize the binding of this antibody an ELISA was performed against biotinylated ERα36 using the scFv version. The scFv version of this antibody can also recognize human ERα36 in a western blot assay. And to identify the therapeutic advantages of this antibody, BCAP-37 tumors were implanted in balb/c nude mice after which the scFv version of this antibody was administered. The tumor sizes showed a significant difference with the control group (US20110311517).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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