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Mfg Part Number

Ab02779-10.3

Vector Labs Ab02779-10.3 Anti-Keratin (4,5,6,8,10,13,18) [C11], Human IgG1, Fc Silent™, kappa (200 μg)

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Quick Overview

The original mouse IgG1 version of this antibody was raised by immunizing mice against human cytoskeleton

$517.40

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Description

Product Class: Purified
Clone ID: C11
Heavy Chain Modification: Fc Silent™
Synonyms: Pan-keratin; Keratin, type II cytoskeletal 5; 58 kDa cytokeratin; Cytokeratin-5; Type-II keratin Kb5
Amount: 200 μg
Application Codes Clone: WB; IHC; IF
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody recognizes the human keratin, types 4, 5, 6, 8, 10, 13, and 18. Because of its wide range in keratin specificity, it often is referred to in literature as pan-keratin.
Application Notes: This original IgG1 antibody can be used to detect human keratin. Its specificity has been confirmed using immunofluorescence (Fehm et al., 2002; PMID: 12114406). One group used immunofluorescence to test if circulating epithelial cells were malignant (Fehm et al., 2002; PMID: 12114406), which was later built upon with the discovery that these cells remained in circulation until many years after treatment (Meng et al., 2004; PMID: 15623589). Another group used the antibodies with immunofluorescence and immunohistochemistry to visualize the progression of breast cancer once it had breached the epithelial cell layer (Khalil et al., 2017; PMID: 28894989). A final group used this antibody with immunofluorescence and western blotting to research the apoptotic response of keracinocytes to ultraviolet-B light (Mei, Lian, 2011; PMID: 21362287).

Product Class:	Purified
Clone ID:	C11
Heavy Chain Modification:	Fc Silent™
Synonyms:	Pan-keratin; Keratin, type II cytoskeletal 5; 58 kDa cytokeratin; Cytokeratin-5; Type-II keratin Kb5
Amount:	200 μg
Application Codes Clone:	WB; IHC; IF
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody recognizes the human keratin, types 4, 5, 6, 8, 10, 13, and 18. Because of its wide range in keratin specificity, it often is referred to in literature as pan-keratin.
Application Notes:	This original IgG1 antibody can be used to detect human keratin. Its specificity has been confirmed using immunofluorescence (Fehm et al., 2002; PMID: 12114406). One group used immunofluorescence to test if circulating epithelial cells were malignant (Fehm et al., 2002; PMID: 12114406), which was later built upon with the discovery that these cells remained in circulation until many years after treatment (Meng et al., 2004; PMID: 15623589). Another group used the antibodies with immunofluorescence and immunohistochemistry to visualize the progression of breast cancer once it had breached the epithelial cell layer (Khalil et al., 2017; PMID: 28894989). A final group used this antibody with immunofluorescence and western blotting to research the apoptotic response of keracinocytes to ultraviolet-B light (Mei, Lian, 2011; PMID: 21362287).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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