Mfg Part Number
Ab02806-10.0
Vector Labs Ab02806-10.0 Anti-HIV-1 GP120 [VRC03], Human IgG1, kappa (200 μg)
Quick Overview
The original antibody was generated from human B cells obtained from an HIV infected donor.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | VRC03 |
| Synonyms: | Glycoprotein 120; SU; surface protein gp120; env polyprotein; envelope glycoprotein gp16 |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; SPR; neutralize |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody binds CD4 binding site of the HIV-1 GP120. |
| Application Notes: | The binding profile of this antibody towards HIV-1 GP120 was studied using ELISA and surface plasmon resonance. The original VRC03 IgG1 antibody, successfully neutralizes over 50% of current circulating HIV-1 isolates. (Mascola et al., US8637036). This antibody was reported to bind the resurfaced stabilized core 3 (RSC3) of the mutated HIV-1 envelop glycoprotein that is also capable of binding CD4. The original IgG1 version of this antibody has a binding affinity of KD = 7.31 × 10–8 M. (PMID: 20616233). VRC03 was found to potently inhibit entry into CD4+ T cells of HIV isolated from the latent viral reservoir of infected individuals whose plasma viremia was well controlled by antiretroviral therapy (ART) (PMID: 25157148). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |