Mfg Part Number
Ab02813-23.0
Vector Labs Ab02813-23.0 Anti-Fel d 1 [REGN1909], Rabbit IgG, kappa (200 μg)
Quick Overview
The original antibody was generated by immunizing a Regeneron’s VelocImmune human antibody producing transgenic mouse with recombinant dimeric Fel d 1.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | REGN1909 |
| Synonyms: | Major cat allergen; CH2; AG4; Major allergen I polypeptide chain 2; Allergen Cat-1; Allergen Fel d I-B; Allergen FdI; Fel dI; Fel d 1-B |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; block; SPR; functional assay; crystallization |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG4 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG4 format for improved compatibility with existing reagents assays and techniques. |
| Specificity Statement: | This antibody binds chain 2 of the Fel d 1, major cat allergen. |
| Application Notes: | The original human IgG4 antibody was found to block binding of wild type Fel d 1 binding to IgE with a maximum blockade of 51% in a blocking ELISA. Surface plasmon resonance was used to identify the affinity of the antibody towards recombinant and wild type Fel d 1. Crystal structure of the Fab fragment antibody was studied using X-ray crystallography. This antibody in combination with REGN1908 was found to be promising in treatment of cat allergies. A single SC dose of REGN1908–1909 in patients with cat allergy resulted in rapid and clinically meaningful reduction in total nasal symptoms by blocking the early allergic response to nasal challenge with cat allergen (PMID: 29650949). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |