Mfg Part Number
Ab02819-23.0
Vector Labs Ab02819-23.0 Anti-Acetylcholinesterase [10D], Rabbit IgG, kappa (200 μg)
Quick Overview
The original mouse antibody was generated by immunizing mice with full-length recombinant human acetylcholinesterase (rHuAChE) as immunogen.
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| Product Class: | Purified |
|---|---|
| Clone ID: | 10D |
| Synonyms: | ACHE; AChE; HuAChE |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques. |
| Specificity Statement: | This antibody binds human acetylcholinesterase, which is a cholinergic enzyme primarily found at postsynaptic neuromuscular junctions, especially in muscles and nerves. It immediately breaks down or hydrolyzes acetylcholine (ACh), a naturally occurring neurotransmitter, into acetic acid and choline. |
| Application Notes: | Acetylcholinesterase is an enzyme that catalyzes the breakdown of acetylcholine and of some other choline esters that function as neurotransmitters. The original mouse IgG1 version of this antibody binds human acetylcholinesterase with a binding affinity of 0.4 nM. The binding affinity of mouse IgG1 version for truncated, monomeric recombinant HuAChE was measured by ELISA. This antibody was used in the immunopurification of membrane bound AChE on human RBCs by binding on immobilized antibody for further detection by mass spectrometry. RBC AChE can be used as a biomarker for exposure to organophosphorus pesticides and nerve agents (PMID: 28892361). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |