Mfg Part Number
Ab02825-10.3
Vector Labs Ab02825-10.3 Anti-Tetanus toxoid [9F12], Human IgG1, Fc Silent™, kappa (200 μg)
Quick Overview
The original antibody was generated from the peripheral blood mononuclear cells form human donors after immunization with tetanus toxoids and fusing these lymphocytes with mouse myeloma line P3-X63-Ag 8.653.
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| Product Class: | Purified |
|---|---|
| Clone ID: | 9F12 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | TT; TTx; Tetanus toxin; tetX; Tentoxylysin |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; neutralize; functional assay |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 7926831 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody binds the intact or wild type tetanus toxin of Clostridium tetani. It was also reported to bind the tetanus toxin fragment B. Tetanus toxin is an extremely potent neurotoxin produced by Clostridium tetani. |
| Application Notes: | The screening of hybridoma supernatants to identify binding towards tetanus toxin was done using ELISA. The protective capacity of this antibody against tetanus toxoid was tested using the mouse tetanus toxin neutralization assay. The mice which received the tetanus toxin preincubated with 9F12 were completely protected (PMID: 7174795). The original antibody was used to study the role of gangliosides in the binding and internalization of bacterial toxins (PMID: 11093135). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |