Mfg Part Number
Ab02854-23.0
Vector Labs Ab02854-23.0 Anti-Nipah virus F Site II [4C9], Rabbit IgG, kappa (200 μg)
Quick Overview
The original version of this antibody was raised against the fusion (F) protein of the Nipah virus.
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| Product Class: | Purified |
|---|---|
| Clone ID: | 4C9 |
| Synonyms: | NiV; Fusion glycoprotein; Protein F; Nipah henipavirus |
| Amount: | 200 μg |
| Application Codes Clone: | IP |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific to fusion (F) protein of the Nipah virus. It is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. This clone binds to Site II on F protein in its prefusion state. It crossreacts with HeV F. |
| Application Notes: | This antibody is recommened for the detection and analysis of the fusion (F) protein of the Nipah virus. This clone is specifically useful in IP isolation of both the pre-fusion F protein. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |