Vector Labs Ab02880-10.3 Anti-CD56 [NKINBL1], Human IgG1, Fc Silent™, kappa (200 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: NKINBL1
Heavy Chain Modification: Fc Silent™
Synonyms: NKI-NBL-1; Neural cell adhesion molecule 1; NCAM1; N-CAM-1; NCAM-1
Amount: 200 μg
Application Codes Clone: FC; IHC; WB; depletion
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
Specificity Statement: This antibody is specific for human CD56. CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. Although CD56 is often considered a marker of neural lineage commitment due to its discovery site, CD56 expression is also found in, among others, the hematopoietic system.
Application Notes: To quantify CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages, flow cytometry was performed on multiple human cell lines using the mouse version of this antibody (Lee et al, 1999; pmid:10220446). To determine differences in the expression level of selected adhesion molecules to identify suitable tools for the pre-procedural identification of restenosis patients before angioplasty, flow cytometry was performed on PMBCs using the mouse version of this antibody (Rahimi et al, 2003; pmid:12717693). To test the ability of OM-174 to stimulate in vitro the lytic potential of peripheral blood cells from patients with non-metastatic breast tumour, the mouse version of this antibody was used for NK depletion on mononuclear blood cells (Reisser et al, 1999). The mouse version of this antibody was used in whole full blood for flow cytometry to characterize the coreceptor activity and the expression pattern of alternative coreceptors that are used by HIV-1 to enter the cell (Sharron et al, 2000; pmid:10891428). To determine the specificity of the mouse version of the antibody, a western blot was performed on different CD56 isoforms. This antibody showed no specificity for any isoform (Gattenlöhner et al, 2009; pmid:19246644). To study tumour infiltrating dendritic cells, Tissue samples collected at the time of nephrectomy were used for immunohistochemistry using the mouse version of this antibody (Schwaab et al, 1999; pmid:10411089).

Product Class:	Purified
Clone ID:	NKINBL1
Heavy Chain Modification:	Fc Silent™
Synonyms:	NKI-NBL-1; Neural cell adhesion molecule 1; NCAM1; N-CAM-1; NCAM-1
Amount:	200 μg
Application Codes Clone:	FC; IHC; WB; depletion
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
Specificity Statement:	This antibody is specific for human CD56. CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. Although CD56 is often considered a marker of neural lineage commitment due to its discovery site, CD56 expression is also found in, among others, the hematopoietic system.
Application Notes:	To quantify CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages, flow cytometry was performed on multiple human cell lines using the mouse version of this antibody (Lee et al, 1999; pmid:10220446). To determine differences in the expression level of selected adhesion molecules to identify suitable tools for the pre-procedural identification of restenosis patients before angioplasty, flow cytometry was performed on PMBCs using the mouse version of this antibody (Rahimi et al, 2003; pmid:12717693). To test the ability of OM-174 to stimulate in vitro the lytic potential of peripheral blood cells from patients with non-metastatic breast tumour, the mouse version of this antibody was used for NK depletion on mononuclear blood cells (Reisser et al, 1999). The mouse version of this antibody was used in whole full blood for flow cytometry to characterize the coreceptor activity and the expression pattern of alternative coreceptors that are used by HIV-1 to enter the cell (Sharron et al, 2000; pmid:10891428). To determine the specificity of the mouse version of the antibody, a western blot was performed on different CD56 isoforms. This antibody showed no specificity for any isoform (Gattenlöhner et al, 2009; pmid:19246644). To study tumour infiltrating dendritic cells, Tissue samples collected at the time of nephrectomy were used for immunohistochemistry using the mouse version of this antibody (Schwaab et al, 1999; pmid:10411089).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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