Mfg Part Number
Ab02884-10.3
Vector Labs Ab02884-10.3 Anti-CD51 [NKI-M9], Human IgG1, Fc Silent™, kappa (200 μg)
Quick Overview
The mouse version of this antibody was raised by immunizing a BALB/c mouse with cultured melanoma cells derived from a human melanoma metastasis.
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| Product Class: | Purified |
|---|---|
| Clone ID: | NKI-M9 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | Integrin alpha-V; ITGAV; Vitronectin receptor; Vitronectin receptor subunit alpha |
| Amount: | 200 μg |
| Application Codes Clone: | FC; functional assay; IHC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format for improved compatibility with existing reagents assays and techniques. |
| Specificity Statement: | This antibody is specific for human CD51. CD51 is a receptor for vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. |
| Application Notes: | To study MSCs as a promising therapeutic agents for a variety of diseases, flow cytometry was performed on human MSCs using the mouse version of this antibody (Wang et al, 2015; pmid:26148841). To study how Bordetella pertussis enters respiratory epithelial cells, an invasion assay was performed using the mouse version of this antibody on human lung epithelial cell line A549 with Bordetella pertussis (Ishibashi et al, 2001; pmid:11373122). To find surface markers specific for Nestin+ cells, flow cytometry was performed on mouse BM primary cells using the mouse version of this antibody. Furthermore, human foetal bones and HA/TCP grafts were stained using this antibody (Pinho et al, 2013; pmid:23776077). To investigate the developmental pathway for human megakaryocytes, flow cytometry was performed on BM HSPCs from healthy donors using the mouse version of this antibody (Miyawaki et al, 2017; pmid:28336526). To determine if OCs express other membrane receptors for matrix proteins, immunohistochemistry was performed on human joint revision capsule tissue using the mouse version of this antibody (Quinn et al, 1991; pmid:1717412). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |