Mfg Part Number
Ab02915-1.1
Vector Labs Ab02915-1.1 Anti-POVPC/PGPC [10C12], Mouse IgG1, kappa (200 μg)
Quick Overview
The mouse version of this antibody was generated by feeding an ApoE KO mice with a high-fat western diet.
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| Product Class: | Purified |
|---|---|
| Clone ID: | 10C12 |
| Synonyms: | POVPC; PGPC |
| Amount: | 200 μg |
| Application Codes Clone: | functional assay; SPR; IF; ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgM |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgM format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for oxidized phospholipids POVPC and PGPC. These are lipids play an important role in cardiovascular disease. |
| Application Notes: | When injected in ApoE KO mice, the mouse version of this antibody decreased accumulation of macrophages in the brachiocephalic artery and decreased OxPL-induced inflammatory response (Cherepanova and Owens, 2014). To study the binding of its ligands a surface plasmon resonance experiment was preformed on POVPC, PGPC and DMPC using the mouse version of this antibody. Modified Russell-Movat (Movat) staining for morphometric analysis of the brachiocephalic arteries was preformed using the mouse version of this antibody. To confirm the binding of this antibody to POVPC and PGPC an ELISA was preformed (Cherepanova et al, 2019; pmid:31645128). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |