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Mfg Part Number

Ab02935-10.3

Vector Labs Ab02935-10.3 Anti-PCSK9 [mAb1], Human IgG1, Fc Silent™, kappa (200 μg)

VECTOR LABS

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Vector Labs Ab02935-10.3 Anti-PCSK9 [mAb1], Human IgG1, Fc Silent™, kappa (200 μg)

$517.40

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Description

Product Class: Purified
Clone ID: mAb1
Heavy Chain Modification: Fc Silent™
Synonyms: NARC1; NARC-1; PC9; Proprotein convertase subtilisin/kexin type; Neural apoptosis-regulated convertase 1; Proprotein convertase 9; Subtilisin/kexin-like protease PC9
Amount: 200 μg
Application Codes Clone: ELISA; functional assay
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Specificity Statement: This antibody binds module 1 of the C-terminal domain (CTD) of PCSK9. It was reported to interact with amino acid residues R469, R496 and F515 of the human PCSK9. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease enzyme encoded by the PCSK9 gene in humans and it plays a role in regulation of circulating cholesterol. It is associated with autosomal dominant hypercholesterolemia, a state of elevated levels of LDL (low-density lipoprotein) cholesterol. Autosomal dominant hypercholesterolemia can result in severe implications such as stroke and coronary heart disease.
Application Notes: Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates serum LDL cholesterol (LDL-C) by interacting with the LDL receptor (LDLR) and is an attractive therapeutic target for LDL-C lowering. This antibody blocks access to an area bearing several naturally occurring gain-of-function and loss-of-function mutations. This antibody does not completely inhibit binding of PCSK9 to epidermal growth factor-like repeat A, it partially reverses PCSK9-induced reduction of the LDLR and LDL cholesterol uptake in a cellular assay. This antibody was also reported to be effective in lowering serum levels of LDL cholesterol in cynomolgus monkeys in vivo (PMID: 24252255).

Product Class:	Purified
Clone ID:	mAb1
Heavy Chain Modification:	Fc Silent™
Synonyms:	NARC1; NARC-1; PC9; Proprotein convertase subtilisin/kexin type; Neural apoptosis-regulated convertase 1; Proprotein convertase 9; Subtilisin/kexin-like protease PC9
Amount:	200 μg
Application Codes Clone:	ELISA; functional assay
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Specificity Statement:	This antibody binds module 1 of the C-terminal domain (CTD) of PCSK9. It was reported to interact with amino acid residues R469, R496 and F515 of the human PCSK9. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease enzyme encoded by the PCSK9 gene in humans and it plays a role in regulation of circulating cholesterol. It is associated with autosomal dominant hypercholesterolemia, a state of elevated levels of LDL (low-density lipoprotein) cholesterol. Autosomal dominant hypercholesterolemia can result in severe implications such as stroke and coronary heart disease.
Application Notes:	Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates serum LDL cholesterol (LDL-C) by interacting with the LDL receptor (LDLR) and is an attractive therapeutic target for LDL-C lowering. This antibody blocks access to an area bearing several naturally occurring gain-of-function and loss-of-function mutations. This antibody does not completely inhibit binding of PCSK9 to epidermal growth factor-like repeat A, it partially reverses PCSK9-induced reduction of the LDLR and LDL cholesterol uptake in a cellular assay. This antibody was also reported to be effective in lowering serum levels of LDL cholesterol in cynomolgus monkeys in vivo (PMID: 24252255).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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