Mfg Part Number
Ab02947-3.3
Vector Labs Ab02947-3.3 Anti-IL-2 [UFKA-20], Mouse IgG2b, Fc Silent™, kappa (200 μg)
Quick Overview
The original antibody was generated immunizing Balb/c mice with human IL-2.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | UFKA-20 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | IL2; IL-2; TCGF; Interleukin-2; T-cell growth factor; Aldesleukin |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; FC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques. |
| Specificity Statement: | This antibody binds human IL-2. In particular, the antibody binds IL-2 dorsolaterally, with an angle of 55° counterclockwise to the vertical axis, contacting the C- and B-helices of IL-2 and thereby forming a “clamp” around the C-helix. The antibody engages IL-2 residues D84, N88, V91, E61, E68, and K64. |
| Application Notes: | This antibody binds to Interleukin-2, a protein produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/UFKA-20 complex shows an improved selectivity towards regulatory T cells compared to IL-2 alone. IL-2/UFKA-20 can recognize the receptor IL of regulatory T cells on the base of the presence of CD25, therefore called CD25 bias. IL-2/UFKA-20 complex is able to efficiently stimulate CD25+ Treg cells in mice and rhesus macaques in vivo as well as in humans ex vivo. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |