Mfg Part Number
Ab02975-1.1
Vector Labs Ab02975-1.1 Anti-Norovirus capsid protein VP1 [A1227], Mouse IgG1, kappa (200 μg)
Quick Overview
The original antibody was isolated from an anti-NoV GII.4c IgG serum antibody repertoire generated from three donors that experienced a significant increase in GII.4 titer after immunization with the bivalent GII.4c + GI.1 VLP vaccine.
$517.40
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | A1227 |
| Synonyms: | VP1; CP; p59; soluble capsid protein; Protein 30k; p30; Norwalk virus |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques. |
| Specificity Statement: | This antibody shows broadly binding but no blocking activity toward multiple GI and GII strains such as GI.I, GII.2, and GII.17. This antibody recognizes a highly conserved epitope located at an occluded site on the norovirus capsid, at the interface between the P domain and shell domain of the Norovirus, which explain its high level of cross-reactivity. Norovirus (NoVs) is one of the main pathogens causing sporadic cases and large outbreaks of acute gastroenteritis, and norovirus can infect people of all ages. |
| Application Notes: | ELISA was used to determine the binding specificity of the antibody for variety of GI and GII genotype VLP. This antibody is capable of recognizing GI.1, GI.3, GI.4, GII.1, GII.2, GII.3, GII.4c, GII.14, GII.17 in an ELISA. This antibody is not capable of neutralizing Norovirus (PMID: 31216462). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |